Pharmaceutical industry

Why not using plant extracts for screening new ingredients?

Resent research has demonstrated that 20% of the crude extracts made from flower bulbs contain activity against bacteria. The results offer you the unique opportunity to screen our extracts to mine the chemo diversity found in various bulb species, for example tulips, hyacinths, and other plants, cultivated in The Netherlands for discovering new leads to protect humans, animals and plants.

Why ingredients from plants which are grown in The Netherlands?

Features

  • Compliance with the strictest quality requirements can be provided by growth under GAP (Good Agricultural Practice):
  • Quality control of plant material via GC(-MS), HPLC (-MS), 1HNMR or 13CNMR.
  • Contract cultivation: production under controlled condition in greenhouses, as well as at lower cost in the field;
  • Extraction under GMP (Good Manufacturing Practice);
  • This ascertains the supply of uniform, high quality raw materials and extracts that are acceptable under any applicable regulatory regime;
  • Highly efficient infrastructure.

Benefits

  • Safeguarding future deliveries;
  • Long term supply-chain relationship;
  • The flower bulb species in the collection of Holland Biodiversity are not subject to the Biological Diversity Treaty (29/12/1993): avoiding legal hassle;
  • Source identification by Scientific Support;
  • Marketing topics: Dutch flowers, green & sustainable.

Case

Daffodils: Not just beautiful! In the nineties of the last century, the compound galantamine, present in daffodils and snowdrops, was found to be an effective treatment for the symptoms of Alzheimer’s disease. We produce tons of bulbs from daffodils for the extraction and isolation of galantamine.

 

Products:

Narcissus: API: galantamine

Galantamine C17H21NO3

CAS Registry Number: 357-70-0

Galantamine is an alkaloid, is a medication and most commonly used for the treatment of mild to moderate Alzheimer’s disease and various other memory impairments.

Gloriosa: API: colchicine
Colchicums: API: colchicine

Colchicine C22H25NO6

CAS Registry Number: 64-86-8

Colchicine is an alkaloid, is a medication and most commonly used to treat gout

Research & Development services

We investigate plants for becoming a unique source for an active ingredient or active extract together in both public and private research partnerships.

  • Metabolomics profile using GC(-MS), HPLC(-MS), 1HNMR or 13CNMR, or an extensive metabolomics study with identification of known compounds
  • Pre-fractionation of extracts by centrifugal partitioning chromatography
  • Isolation of (biologically active) compounds
  • Protocol development on lab scale
  • Crop optimization for optimizing the in-planta levels of a compound of interest, which in turn results in reduced raw material cost.
  • Breeding new plant varieties for optimizing the in-planta levels of a compound of interest, which results in reduced raw material cost.